|Manufactured By:||Spectrum Chemical Manufacturing Corporation, USA|
A cyclodextrin that allows easier diffusion of lipophiles across biological membranes.
2-Hydroxypropyl-beta-cyclodextrin (EP, USP, BP, JP) Grade is the most widely used modified cyclodextrin. The compound has shown to change the physicochemical properties of lipophilic compounds when co-administered. 2-Hydroxypropyl-β-cyclodextrin functions by forming an inclusion complex with the compound being administered for easier diffusion across biological membranes, and its popularity can be attributed to its large 7 glucose unit cavity size. Some advantageous effects are reduction of negative effects, increased aqueous solubility and increased stability. The effects of 2-Hydroxypropyl-β-cyclodextrin have been observed to be dose dependent with both advantageous and disadvantageous results occurring at sporadic concentrations. The compound may also increase the antimicrobial effectiveness of chemical agents by increasing their release rate.